2024

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O. Tepper, D. H. Appella, H. Zheng, R. Dzikowskic, and E. Yavin A biotinylated cpFIT-PNA platform for the facile detection of drug resistance to Artemisinin in Plasmodium falciparum, ACS Sensors, 2024, accepted. 

https://doi.org/10.1021/acssensors.3c02553

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2022

O. Tepper, I. Peled, Y. Fastman, A. Heinberg, V. Mitesser, R. Dzikowski, and E. Yavin, FIT-PNAs as RNA sensing probes for drug-resistant Plasmodium falciparum, ACS Sensors, 2022, https://doi.org/10.1021/acssensors.1c01481

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2021

O. Tepper, H. Zheng, D. H. Appella, and E. Yavin, Cyclopentane FIT-PNAs: bright RNA sensors, Chem. Commun., 2021, 57, 540-543.

 

2020

E. Yavin, Peptide Nucleic Acids: Applications in Biomedical Sciences, Molecules 2020, 25(15) (Edited Book)

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2019

T. Soudah, S. Khawaled, R. I. Aqeilan, and E. Yavin, AntimiR-155 Cyclic Peptide−PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity, ACS Omega, 2019, 4, 13954-13961.

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D. Hashoul, R. Shapira, M. Falchenko, O. Tepper, V. Paviov, A. Nissan, and E. Yavin, Red-emitting FIT-PNAs: "On Site" Detection of RNA Biomarkers in Fresh Human Cancer Tissues, Biosensors Bioelect. 2019, 137, 271-278.

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P. Denichenko, M. Mogilevsky, A. Cléry, T. Welte, J. Biran, O. Shimshon, G. D, Barnabas, M. Danan-Gotthold, S. Kumar, E. Yavin, E. Y. Levanon, F. H. Allain, T. Geiger, G. Levkowitz, and R. Karni, Specific inhibition of splicing factor activity by decoy RNA oligonucleotides, Nature Commun. 2019, 10. 1590.

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V. V. Maximov, R. Akkawi, S. Khawaled, Z. Salah, L. Jaber, A. Barhoum, O. Or, M. Galasso, K. C. Kurek, E. Yavin, and R. I. Aqeilan, MiR‐16‐1‐3p and miR‐16‐2‐3p possess strong tumor suppressive and anti‐metastatic properties in osteosarcoma, Int J. Cancer, 2019, 145, 3052-3063.

 

2018

M. Mogilevsky, O. Shimshon, S. Kumar, A. Mogilevsky, E. Keshet, E. Yavin, F. Heyd, R. Karni, Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment, Nucl. Acids Res. 2018, 30; 46(21), 11396-11404.

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I. Peled and E. Yavin, A predictive model for the sequence-dependent fluorogenic response of forced-intercalation Peptide Nucleic Acid (FIT-PNA), ACS Omega 2018, 3, 3813-3818.

 

2017

O. Amsalem, T. Nassar, S. Benhamron, P. Lazarovici, S. Benita and E. Yavin, Solid Nano-in-Nanoparticles for Potential Delivery of siRNA, J. Controlled Rel. 2017, 257, 144-155.

 

M. B. D. Bloch, E. Yavin, A. Nissan, I. Ariel, R. Kenett, D. Brass and A. Rubinstein, The effect of linker type and recognition peptide conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide. J. Controlled Rel. 2017, 257, 102-117.

 

T. Soudah, M. Mogilevsky, R. Karni, and E. Yavin, CLIP6-PNA-peptide Conjugates: Non-endosomal Delivery of Splice Switching Oligonucleotides (SSO), Bioconjugate Chem. 2017, 28, 3036-3042.

 

2016

N. Kolevzon, D. Hashoul, S. Naik, A. Rubinstein and E. Yavin, Single Point Mutation Detection in Living Cancer Cells by Far-red Emitting PNA-FIT Probes, Chem. Commun. 2016, 52, 2405-2407.

 

2015

M. Bloch, L. Jablonowski, E. Yavin, D. Moradov, I. Djavsarov, A. Nyska, M. Wheatley, and A. Rubinstein, Multi-modal detection of colon malignancy by NIR-tagged recognition polymers and ultrasound contrast agents, Int. J. Pharm. 2015, 504-516.

 

I. Avraham, G. Pozner, S. Eshar, Y. Fastman, N. Kolevzon, E. Yavin and R. Dzikowski, Antisense lncRNAs regulate var gene activation in the malaria parasite Plasmodium falciparum, Proc. Natl. Acad. Sci. USA, 2015, 112(9), E982-E991.

 

M. Bloch, R. Kenett, L. Jablonowski, M. Wheatley, E. Yavin and A. Rubinstein, A multifactorial analysis of complex pharmaceutical platforms: an application of design of experiments to targetable polyacrylamide and ultrasound contrast agents, Polym. Adv. Technol. 2015, 26, 898-905.

 

Y. Shemesh and E. Yavin, Post-synthetic conjugation of RNA to carboxylate and dicarboxylate molecules, Nucleosides, Nucleotides and Nucleic Acids 2015, 34(11), 753-762.

 

Y. Shemesh and E. Yavin, PNA-Rose Bengal Conjugates as Efficient DNA Photomodulators, Bioconjugate Chem. 2015, 26, 1916-1922.

 

2014

M. Kovaliov, M. Segal, P. Kafri, E. Yavin, Y. Shav-Tal and B. Fischer, Detection of Cyclin D1 mRNA by hybridization sensitive NIC - oligonucleotide probe, Bioorg. Med. Chem. 2014, 22(9), 2613-2621.

 

L. Zilbershtein-Shklanovsky, P. Kafri, Y. Shav-Tal, E. Yavin, and B. Fischer, Development of fluorescent double-strand probes labeled with  8-(p-CF3-cinnamyl)-adenosine for the detection of  cyclin D1 breast cancer marker, Eur. J. Med. Chem. 2014, 79, 77-88.

 

M. Kovaliov, C. Wachtel, E. Yavin, and B. Fischer, Synthesis and evaluation of a photoresponsive quencher for fluorescent hybridization probes, Org. Biomol. Chem. 2014, 12(39), 7844-7858.

 

T. Shekh-Ahmad, H. Mawasi, J. H. McDonough, R. H. Finnell, B. J. Wlodarczyk, E. Yavin, and M. Bialer, Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid, Epilepsia 2014, 55, 1944-1951.

 

E. Wexselblatt, R. Raveendran, S. Salameh, A. Friedman-Ezra, E. Yavin, and D. Gibson, On the stability of Pt(IV) pro-drugs with haloacetato ligands in the axial positions, Chem. Eur. J. 2014, 21, 3108-3114.

 

2013

N. Kolevzon, A. Nasereddin S. Naik, E. Yavin, and R. Dzikowski, Use of peptide nucleic acids to manipulate gene expression in P. falciparum, Plos One, 2013, 9(1), e86802.

 

E. Wexselblatt, E. Yavin, D. Gibson, PtIV pro-drugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions, Angew. Chem. Int. Ed. 2013, 52, 6059-6062.

 

N. Dahan-Pasternak, A. Nasereddin, N. Kolevzon, M. Pe'er, W. Wong, V. Shinder, L. Turnbull, C. Whitchurch, M. Elbaum, T. W. Gilberger, E. Yavin, J. Baum, and R. Dzikowski, PfSec13 is an unusual chromatin associated nucleoporin of Plasmodium falciparum, which is essential for parasite proliferation in human erythrocytes, J. Cell Sci. 2013, 126, 3055-3069.

 

M. Segal, E. Yavin, P. Kafri, Y. Shav-Tal and B. Fischer, Detection of mRNA of Cyclin D1 breast cancer marker by a novel duplex-DNA probe, J. Med. Chem. 2013, 56, 4860-4869.

 

E. Wexselblatt, I. Kaspy, G. Glaser, J. Katzhendler and E. Yavin, Design, Synthesis and Structure-Activity Relationship of novel Relacin analogues as inhibitors of Rel proteins, Eur. J. Med. Chem. 2013, 70, 497-504.

 

Y. Kam, A. Rubinstein, S. Naik, I. Djavsarov,  D. Halle, I. Ariel, A. O. Gure, V. Tsivin, A. Nissan, E. Yavin, Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons, Cancer Lett. 2014, 352, 90-96.

 

E. Z. Khvalevsky, R. Gabai, I. H. Rachmut, E. Horwitz, Z. Brunschwig, A. Orbach, A. Shemi, T. Golan, A. J. Domb, E. Yavin, H. Giladi, L. Rivkin, A. Simerzin, R. Eliakim, A. Khalaileh, A. Hubert, M. Lahav, Y. Kopelman, E. Goldii, A. Dancour, Y. Hants, S. Arbel-Alon, R. Abramovitch, A. Shemi, and E. Galun, Mutant KRAS is a druggable target for pancreatic cancer, Proc. Natl. Acad. Sci. 2013, 110, 20723-70728.

 

2012

T. Shekh-Ahmad, M. Bialer and E. Yavin, Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue, Epilepsy Res. 2012, 98, 238-246.

 

E. Khazanov, E. Yavin, A. Pascal, A. Nissan,Y, Kohl, M, Reimann-Zawadzki and A. Rubinstein, Detecting a Secreted Gastric Cancer Biomarker Molecule by Targeted Nanoparticles for Real-Time Diagnostics, Pharm. Res. 2012, 29, 983-993.

 

Y. Kam, A. Rubinstein, A. Nissan, D. Halle and E. Yavin, Detection of endogenous k-RAS mRNA in living cells at a single base resolution by a PNA molecular beacon, Mol. Pharm. 2012, 9, 685-693.  

 

M. Bloch, Y. Kam, E. Yavin, D. Moradov, A. Nissan, I. Ariel, and A. Rubinstein, The relative roles of charge and a recognition peptide in luminal targeting of colorectal cancer by fluorescent polyacrylamide, Eur. J. Pharm. Sci. 2012, 47, 904-913.

 

E.Wexselblatt, Y. Oppenheimer-Shaanan, I. Kaspy, N. London, O. Schueler-Furman, E. Yavin, G. Glaser, J. Kathendler, S. Ben-Yehuda, Relacin, a Novel Antibacterial Agent Targeting the Stringent Response, Plos Pathogens 2012, 8(9)  e1002925.

 

E. Wexselblatt, E. Yavin, D. Gibson, Cellular interactions of platinum drugs, Inorg. Chimica Acta 2012, 393, 75-83.

 

2011

Y. Oppenheimer-Shaanan, E. Wexselblatt, J. Katzhendler, E. Yavin and S. Ben-Yehuda, c-di-AMP Reports DNA Integrity during Sporulation in B. subtilis, EMBO Reports 2011, 112(6), 594-601.

 

N. Kolevzon, U. Kuflik, M. Shmuel, S. Benhamron, I. Ringel and E. Yavin, Multiple Triphenylphosphonium Cations as a Platform for the Delivery of a Pro-Apoptotic Peptide, Pharm. Res. 2011, 28:2780–2789.

 

2010

A. Biton, A. Ezra, J. Kasparkova, V. Brabec and E. Yavin, DNA Photocleavage by DNA and DNA-LNA amino acid-Dye conjugates, Bioconjugate Chem. 2010, 21, 616-621.

 

E. Zobel, E. Yavin, H. E. Gottlieb, M. Segal and B. Fischer, Oligonucleotides are Potent Antioxidants Acting Primarily through Metal Ion Chelation, J. Biol. Inorg. Chem. 2010, 15, 601-620.

 

E. Khazanov, N. Emmanuel, A. Kareem Azab, Y. Barenholz, E. Yavin and A. Rubinstein, Specific detection of gastric α-antitrypsin by immobilized trypsin on polyHEMA films, Mol. Pharm. 2010, 7, 944-952.

 

S. Alkhader, A. Ezra, J. Kasparkova, V. Brabec and E. Yavin, A Metal-Free DNA Nuclease Based on a Cyclic Peptide Scaffold, Bioconjugate Chem. 2010, 21, 1425-1431.

 

N. Kolevzon and E. Yavin, Site Specific DNA Photocleavage and Photomodulation by Oligonucleotide Conjugates, Oligonucleotides  2010, 20, 263-275.

 

2009

S. E. Abu-Gosh, N. Kolvazon, B. Tirosh, I. Ringel and E. Yavin, Multiple Triphenylphosphonium Cations Shuttle a Hydrophilic Peptide into Mitochondria, Mol. Pharm. 2009, 6, 1138-1144.

 

2007

A. K. Boal, E. Yavin and J. K. Barton, DNA Repair Enzymes with a [4Fe-4S] Cluster: A Redox Cofactor for DNA-mediated Charge Transport, J. Inorg. Biochem. 2007, 101, 1913-1921.

 

A. A. Gorodetsky, O. Green, E. Yavin, and J. K. Barton, Coupling into the Base Pair Stack is Necessary for DNA-mediated Electrochemistry, Bioconjugate Chem.  2007, 18, 1434-1441.

 

2006

E. Yavin, E. D. A. Stemp, V. L. O’Shea, S. S. David, and J. K. Barton, Electron Trap for DNA-bound Repair Enzymes: A Strategy for DNA-mediated Signaling, Proc. Natl. Acad. Sci. USA 2006, 103 (10), 3610-3614.

 

2005

E. Yavin, A. K. Boal, E. D. A. Stemp, E. M. Boon, A. L. Livingston, V. L. O’Shea, S. S. David, and J. K. Barton: Protein–DNA charge transport: Redox activation of a DNA repair protein by guanine radical, Proc. Natl. Acad. Sci. USA 2005, 102 (10), 3546-3551.

 

E. Yavin, R. V. Kikkeri, S. Gil, R. Arad-Yelllin, Ep. Yavin and A. Shanzer, Synthesis and Biological Evaluation of Lipophilic Iron Chelators as Protective Agents From Oxidative Stress, Org. & Biomol. Chem. 2005, 3, 2685-2687.

 

A. K. Boal, E. Yavin, O. A. Lukianova, V. L. O’Shea, S. S. David, and J. K. Barton, DNA-bound Redox Activity of DNA Repair Glycosylases Containing [4Fe-4S] Clusters, Biochemistry 2005, 44 (23), 8397-8407.

 

2004

E. Yavin, E. D. A. Stemp, L. Weiner, I. Sagi, R. Arad-Yellin and A. Shanzer, Direct Photo-Induced DNA Strand Scission by a Ruthenium Bipyridyl Complex, J. Inorg. Biochem. 2004, 98, 1750-1756.

 

E. Yavin, L. Weiner, R. Arad-Yellin and A. Shanzer, Photoinduced Electron Transfer in Ruthenium Bipyridyl Complexes: Evidence for a Cage with Molecular Oxygen, J. Phys. Chem. A 2004, 108, 9274-9282.

 

2001

E. Yavin, L. Weiner, R. Arad-Yellin and A. Shanzer, Controlling the Energy and Electron Transfer in a Novel Ruthenium Bipyridyl Complex: An ESR Study, J. Phys. Chem. A 2001, 105, 8018-8024.